Cognition and Imaging in Neurodegenerative Disease Lead Investigator: Philip Insel Institution : UCSF E-Mail : p_insel@yahoo.com Proposal ID : 114 Proposal Description: Abstract: The primary aim is to develop composites of the cognitive variables that linearize change across diagnoses. Then use this composite to evaluate how rates of change accelerate with respect to physical time in order to estimate the time course of disease progression and the mediation/moderation effects of explanatory variables.